[phenixbb] Research Associate (Fixed Term) at the MRC Mitochondrial Biology Unit, University of Cambridge

Jonathan Ruprecht jjr at mrc-mbu.cam.ac.uk
Wed May 15 02:32:01 PDT 2019

Posting on behalf of Dr Edmund Kunji:

The University of Cambridge wishes to appoint a Postdoctoral scientist 
to join the research group of Dr Edmund Kunji in the MRC Mitochondrial 
Biology Unit of the University of Cambridge.

The postholder will work within a programme focussed on mitochondrial 
transporters. Transport processes are crucial for the functioning of 
mitochondria and mutations in transport proteins cause of a wide range 
of metabolic, neuromuscular and developmental diseases. Basic molecular 
understanding of their structure and mechanism is required to understand 
their role in health and disease.

The goal of the project is to study their structures in different 
conformational states by electron cryo-microscopy and/or x-ray 
crystallography. The post-holder will participate in every stage of the 
process, from the generation of expression strains or cell lines, 
isolation of mitochondria, purification and sample preparation, data 
acquisition and processing, and structure model building and 
interpretation. There will also be an opportunity to study their role 
and mechanism using a wide range of biochemical and biophysical 
techniques. This project is part of a collaborative SNF Sinergia grant 
together with Profs. Hediger and Lochner of the University of Bern.

Candidates will have a PhD in Structural Biology/Biophysics or related 
disciplines, and a track record of research achievements. Knowledge of 
protein purification and experience in structural biology are essential.

Further details about the job may be found here: 

The MRC Mitochondrial Biology Unit is a world-renowned centre for 
mitochondrial research. Additional information can be found at 

Fixed-term: The funds for this post are available for 3 years in the 
first instance.

The closing date for applications is Wednesday 12th June 2019 with 
interview date yet to be confirmed.

Informal enquiries may be made to Dr Edmund Kunji (ek at mrc-mbu.cam.ac.uk).

More information about the phenixbb mailing list