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Great paper indeed!
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<div class="">However quite significant progress seems to have been achieved with ligands (and not only)...<a href="https://deepmind.google/discover/blog/a-glimpse-of-the-next-generation-of-alphafold/" class="">https://deepmind.google/discover/blog/a-glimpse-of-the-next-generation-of-alphafold/</a> </div>
<div class="">Has anyone in the community put this to the test? </div>
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<div style="color: rgb(0, 0, 0);">Best wishes</div>
<div style="color: rgb(0, 0, 0);">Roberto</div>
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<span style="font-style: normal;" class=""><b class="">Roberto A Steiner</b></span><br class="">
<a href="http://www.steinerlab.org/" class="">www.steinerlab.org</a></div>
<div style="color: rgb(0, 0, 0);"><a href="https://twitter.com/steiner_lab" class="">https://twitter.com/steiner_lab</a></div>
<div style="color: rgb(0, 0, 0);"> </div>
<div style="color: rgb(0, 0, 0);"><a href="mailto:roberto.steiner@kcl.ac.uk" class="">roberto.steiner@kcl.ac.uk</a></div>
<div style="color: rgb(0, 0, 0);">Randall Centre for Cell and Molecular Biophysics </div>
<div style="color: rgb(0, 0, 0);">Faculty of Life Sciences and Medicine <br class="">
King's College London <br class="">
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Phone 0044 20 78488216<br class="">
Fax 0044 20 78486435<br class="">
<br class="">
<a href="mailto:roberto.steiner@unipd.it" class="">roberto.steiner@unipd.it</a></div>
<div>Dipartimento di Scienze Biomediche<br class="">
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<div class="">On 30 Nov 2023, at 22:35, Tom Terwilliger <<a href="mailto:tterwilliger@newmexicoconsortium.org" class="">tterwilliger@newmexicoconsortium.org</a>> wrote:</div>
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<div dir="ltr" class="">Hi Structural biologist colleagues! <br class="">
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Our article that helps you make the case that the experiment is still very much needed is now out:
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<div class=""><a href="https://www.nature.com/articles/s41592-023-02087-4" originalsrc="https://www.nature.com/articles/s41592-023-02087-4" shash="YWcJY3E/JkdWk8cWCnGkTsPK+pxLP5XJfqYBeQeQwJ/436WfymMzOEAjCxdhv7Tf+0ItW3hlV1kYhZGJI1mCad5pQu+IkDWbFmng+m1ZHPoJzZ99jreMEsGZJ3pkJIPzZ+xvkUVT0lI+asxokUdmab5crcNBqe3QB44rG+Or03w=" target="_blank" class="">https://www.nature.com/articles/s41592-023-02087-4</a><br class="">
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"AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination." Nature Methods (2023)<br class="">
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Also, here is a video on the Phenix Tutorials YouTube channel that describes this analysis:
<a href="https://www.youtube.com/watch?v=ugMPYdPo8Bc" originalsrc="https://www.youtube.com/watch?v=ugMPYdPo8Bc" shash="oH3xKfZgAiC93hOio8JtPsyDcmqhLQr+8ZvbWBRp7Ur7CPVNdgs1r3m0cBU98ndAxc+t1II50WzdciFV8em75z+19CHRZ2OaEcdBv2x49J6us9sapkhmhuSSNj6OY1tBZTeI8abs+fkdqqytp0DwYhRaNNDP3uhJpYHBTiKEvdg=" target="_blank" class="">
https://www.youtube.com/watch?v=ugMPYdPo8Bc</a>
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<div class="">(I hope you will be happy to see that you and your structural biology colleagues get the credit for making AlphaFold possible at 2:35 in the introduction of this video! Keep up the fantastic structural biology work!)</div>
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<div class="">All the best,</div>
<div class="">Tom T</div>
<span class="gmail_signature_prefix">-- </span><br class="">
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<div dir="ltr" class="">Thomas C Terwilliger
<div class="">Laboratory Fellow, Los Alamos National Laboratory</div>
<div class="">Senior Scientist, New Mexico Consortium</div>
<div class="">100 Entrada Dr, Los Alamos, NM 87544</div>
<div class="">Email: <a href="mailto:tterwilliger@newmexicoconsortium.org" target="_blank" class="">
tterwilliger@newmexicoconsortium.org</a></div>
<div class="">Tel: 505-431-0010</div>
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