<html><body><div style="color:#000; background-color:#fff; font-family:times new roman, new york, times, serif;font-size:12pt"><div><span><br></span></div>Dear All,<br><br>When we run 3 rounds of Phenix refine, both the Rwork and Rfree are satisfactory. However if we run 5 rounds of Phenix refine with the same strategy as the above 3 rounds, in the 4th round Rfree starts to increase until the end of the 5th round.<br><br>Although by the above 3 rounds of Phenix refine we got satisfactory Rwork and Rfree, can we say the results got by that 3 rounds of Phenix refine are acceptable?<br><br>Cheers,<br><br>Dialing<br> <div style="font-family: times new roman, new york, times, serif; font-size: 12pt;"> </div> </div></body></html>