[phenixbb] Postdoctoral Position in Structural Biology at ICR, London, UK

Sebastian Guettler Sebastian.Guettler at icr.ac.uk
Fri Oct 16 03:17:03 PDT 2015

Dear PHENIX Community,

Please see below for details of a postdoctoral position in our team.

Best wishes,
Sebastian Guettler

Postdoctoral Position in Protein Biochemistry / Structural Biology / Electron Microscopy

We seek to appoint a Postdoctoral Training Fellow to the research team led by Dr Sebastian Guettler in the Divisions of Structural and Cancer Biology at The Institute of Cancer Research in London, UK. The position is funded by Cancer Research UK. The successful applicant will undertake biochemical, structural and functional studies on members of the ADP-ribosyltransferase (or “PARP”) family of proteins and macromolecular complexes containing PARPs. Our goal is to gain insight into the control and cellular roles of these enzymes with a specific interest in ADP-ribosyltransferase-dependent signalling processes linked to cancer.

Applicants should possess a PhD in a biological science such as biochemistry or molecular biology. Experience with recombinant DNA techniques, high-quality protein expression and purification, protein characterisation, structural biology, as well as some experience in structural electron microscopy are essential.

Appointment will be on a Fixed Term Contract for 3 years in the first instance. The full salary scale is in the range from £29,517 to £42,187 p.a. inclusive. Starting salary will be based on previous postdoctoral experience.

To apply, please submit your CV and covering letter online. Please include the names and addresses of two referees. For further details and instructions on how to apply, please refer to our online vacancy and recruitment site at http://www.icr.ac.uk/jobsearch, quoting job reference number 1494999  for this position.

While applications need to be placed via our online system, informal inquiries can be sent to Dr Sebastian Guettler at sebastian.guettler at icr.ac.uk<mailto:sebastian.guettler at icr.ac.uk>. Please do not submit your formal application by email!

Closing Date of vacancy: 31 Oct 2015
Type of Contract: Fixed Term, Postdoctoral Training Fellow
Length of Contract: 3 years
Salary Range: £29,517 p.a - £42,187 p.a. inclusive (full salary scale)
Work Location: London

Research in the Divisions of Structural and Cancer Biology focuses on the functional, biochemical, and structural characterisation of cellular processes relevant to cancer and cancer therapy. The Division of Structural Biology has managed state-of-the-art facilities for protein crystallography (crystallisation robots, Bruker Microstar and CCD detector), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60-litre fermentor). The Division is also well-equipped with instrumentation for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). The Division of Cancer Biology provides a state-of-the-art infrastructure for mammalian cell culture, imaging, mammalian genetics, chemical biology and proteomics.

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP.

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