[phenixbb] Ringer: A program to detect molecular motions by systematic X-ray electron-density sampling

[Terry Lang]

The Alber lab at UC Berkeley is pleased to release of the code for 
Ringer version 1.0 (http://ucxray.berkeley.edu/ringer.htm).  Ringer is a 
program to detect molecular motions by systematic X-ray electron-density 
sampling. The aim of Ringer is to go beyond static structural snapshots 
of proteins by uncovering structural ensembles in X-ray electron 
density. This information can reveal not only which parts of proteins 
are flexible and which parts are rigid, but it also can define alternate 
conformations that may be important for function. Alternate 
conformations of binding sites also may afford additional targets for 
drug design.  The Ringer method is described in Lang et al. /Protein 
Sci/. 2010 Jul; 19(7):1420-31 
<http://www.ncbi.nlm.nih.gov/pubmed/20499387>.  An application of 
Ringer, determining the structural underpinnings of the side chain 
dynamics critical for the function of the enzyme proline isomerase, was 
published in Fraser JS et al. /Nature/. 2009 Dec 3;462(7273):669-73 
<http://www.ncbi.nlm.nih.gov/pubmed/19956261>.  Ringer is freely 
available to academics.

-- 
PaulaTherese Lang
Postdoctoral Scholar
Alber Lab, UC Berkeley
http://ucxray.berkeley.edu/ringer.htm